Proline and 1-(2-(benzoxazole-2-yl)phenyl)-3-phenylthiourea supramolecular organocatalyst in asymmetric aldol reactions
Lopez Ruíz, Heraclio
2021
Verónica Díaz-Juárez, Carlos Ernesto Reyes-Escobedo, Mario Pérez-Venegas, Eusebio Juaristi,, Salvador Pérez-Estrada, Susana Rojas-Lima, Heraclio López-Ruiz. Proline and 1-(2-(benzoxazole-2-yl)phenyl)-3-phenylthiourea supramolecular organocatalyst in asymmetric aldol reactions. Tetrahedron Letters, 2021, 79, 153301
Abstract
In this work we report the (S)-proline-thiourea 1 host?guest complex as an efficient catalyst in the enantioselective aldol rection of ketones with aldehydes. This host?guest complex performs well at 0 C, in a non-polar solvent, such as toluene, or under solvent-less conditions affording high yields (75%-86%), enantioselectivities (er > 87%) and diastereoselectivities (ds > 92%) in the asymmetric aldol reaction of ketones with aldehydes.
Artículos relacionados
Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles
Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.
Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition
Et3B, an Efficient Mediator for Xanthate Transfer Based Radical Processes
Synthesis of new homochiral 2,3-dialkylpiperazines derived from (R)-(?)-phenylglycinol