Producción Científica Profesorado

Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT



Mendoza Huizar, Luis Humberto

2021

Miriam Franco-Guzmán, Luis Humberto Mendoza-Huizar, Gabriela Roa-Morales, Carlos Andrés Galán-Vidal and Giaan Arturo Álvarez-Romero, Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT. J. Electrochem. Soc., 2021, 168, 037502


Abstract


This work describes the development of a voltammetric methodology based on a carbon paste electrode enriched with multiwalled carbon nanotubes and TiO2 nanoparticles, for the electrochemical quantification of diclofenac. All stages of the methodology were optimized by a Box-Behnken experimental design. The electrochemical behavior of diclofenac was studied by cyclic voltammetry. Results showed that the oxidation of diclofenac is favored by the presence of both MWCNT and TiO2 nanostructures since a considerable increase in the anodic peak current is observed when compared to a that obtained with a bare carbon paste electrode. Under the optimal values found and with the appropriate statistical analysis, a LOD of 0.33 ?M, a LOQ of 1.11 ?M, a linear concentration range from 1.1 × 10?6 to 5 × 10?3 M (R2 = 0.9958), and a sensitivity of 0.487 ?A.?M?1 were found. The electrode's response was precise as the reproducibility resulted to be 4.39% (%RSD). Finally, a study of possible interferences was performed, along with the quantification of diclofenac in pharmaceutical samples by the proposed voltammetric methodology. The voltammetric method was validated by comparing the results with those obtained with the UV?vis spectrophotometric method.






Artículos relacionados

Effect of TiO2-Al2O3 sol-gel supports on the superficial Ni and Mo species in oxidized and sulfided ...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Electrochemical kinetic study about cobalt electrodeposition onto GCE and HOPG substrates from sulfa...

Magnetic transition phase diagram of cobalt clusters electrodeposited on HOPG: Experimental and micr...

Quantum chemical study of the electrochemical reduction of the [Co(H2O)6]2+ and [Co(NH3)5(H2O)]2+ io...

The role of temperature in copper electrocrystallization in ammoniachloride solutions

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing di...

A Semiempirical PM6 Study of Some Aminopyrimidine Derivatives and their Interaction with an Iron Sur...

Nucleation and growth of cobalt onto different substrates: Part II. The upd-opd transition onto a go...

ELECTROCHEMICAL STUDY ABOUT ZINC ELECTRODEPOSITION ONTO GCE AND HOPG SUBSTRATES