2019
Simplicio González-Montiel, René Velázquez-Jiménez , Diego Martínez-Otero, Daniel Mendoza-Espinosa, J. Manuel Vásquez-Pérez, Noemí Andrade-López, Julián Cruz-Borbolla, Oscar Muñoz-Granados, Journal of Molecular Structure 1176 (2019) 54-65 doi:10.1016/j.molstruc.2018.08.060
Abstract
Monoaza-dithia- (1a e 3a) and diaza-tetrathia- (1b and 3b) macrocycles with a pendant 2-pyridylmethylfragment have been prepared by the reaction between 2-(aminomethyl)pyridine with dibromidedithioetherderivatives. Four of the macrocycles have been characterized by X-ray crystallography,revealing the formation of two 14- and 15-membered monoaza-dithiaethers, and two 26- and 30-membered diaza-tetrathiaether macrocycles featuring one or two exo-2-pyridylmethyl fragments,respectively. The monoaza-dithiaethers macrorings adopt a twisted conformation while the diazatetrathiaethersmacrorings display a rectangular conformation. Intramolecular interactions of macrorings2a, 3a, 1b and 3b were studied by non-covalent interaction analysis. It was found that smallermacrorings are less stable than larger ones due to larger strain energies and that intramoleculardispersive interactions and hydrogen bonding play an important role in the macrocycle conformationadopted.
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives
Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase
First Total Synthesis of ()-Flustraminol B
Configuration, stereodynamics and crystal structure of 3-substituted-2-oxofuro[2,3-b]indoles
Synthesis of Indolylindolines Mediated by tert-BuNH2
Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor
13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters