2014
Mendoza-Espinosa, D. Negrón-Silva, G. Lomas-Romero, L.; Gutiérrez-Carrillo, A.; Santillán, R. Pseudo-Four-Component Click Preparation of N-benzyl substituted 1,2,3-triazols based in Aniline. Molecules, 2014, 19, 55-66.
Abstract
he pseudo-four component click synthesis of dibenzylated 1,2,3-triazoles derived from aniline is reported. The cycloaddition of sodium azide to N-(prop-2-ynyl)-benzenamine (I) in the presence of equimolar amounts of p-substituted benzyl derivatives, yields a mixture of mono- and dibenzylated 1,2,3-triazoles. When two equivalents of the benzyl derivative are added to the multicomponent reaction, the selective preparation of the dibenzylated compounds is achieved. The reactivity of the aniline N-H bond in monobenzylated 1,2,3-triazoles was tested by treatment with one equivalent of a p-substituted benzyl chloride at 40 C, rendering the dibenzylated derivatives quantitatively.
Synthesis of Indolylindolines Mediated by tert-BuNH2
Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor
Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase
Transesterifications mediated by t-BuNH2
The absoluteconfiguration of cuauhtemone and related compounds
Cleavage of alkoxycarbonyl protecting groups from carbamates by t-BuNH2
Total Syntheses of Five Indole Alkaloids from the Marine Bryozoan Flustra foliacea
One-potsynthesis of conformationallyrestrictedspirooxindoles
13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters