Producción Científica Profesorado

Facile One-pot Synthesis of 1,2,3-triazoles Featuring Oxygen, Nitrogen and Sulfur Pendant Arms. Synthetic Commun., 2014, 44, 807-817.



Mendoza Espinosa, Daniel

2014

Mendoza-Espinosa, D. Negrón-Silva, G. Lomas-Romero, L.; Gutiérrez-Carrillo, A.; Santillán, R. Facile One-pot Synthesis of 1,2,3-triazoles Featuring Oxygen, Nitrogen and Sulfur Pendant Arms. Synthetic Commun., 2014, 44, 807-817.


Abstract


A practical and efficient one-pot synthesis of novel 1,2,3-triazoles featuring nitrogen, oxygen, and sulfur functionalized pendant arms has been developed. The click reaction of mono-propargyl derivatives supported by aniline, thiophenol, and benzyl alcohol, with sodium azide and p-substituted benzyl halogenides, renders a series of N-substituted-1,2,3-triazoles in good yields under mild reaction conditions. The catalyst system was based in Cu(OAc)2 H2O, sodium L-ascorbate, and 1,10-phenanthroline monohydrate, and all reactions were performed in a mixture H2O?ethanol (4:1 v/v). Additionally, the preparation of bis-1,2,3-triazoles supported by di-propargylated aniline was carried out, demonstrating the versatility of the present methodology.



Producto de Investigación




Artículos relacionados

Synthesis of ?4:?2-Exocyclic-Diene Iridium(I) Complexes Derived from 1,3-Oxazolidin-2-ones and Their...

Configuration, stereodynamics and crystal structure of 3-substituted-2-oxofuro[2,3-b]indoles

13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters

Aromatic Bromination versus Oxidation of Indolylmalonates by Bromine

Cascade [1,3]-Sigmatropic Rearrangements of Ketene O,O-Acetals: Kinetic and DFT Level Mechanistic St...

Synthesis of Bromoindole Alkaloids from Laurencia brongniartii

Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase

Synthesis of Acetamido(indol-3-yl)propanol Derivatives

Regioselective Synthesis of 3-Indolyl(alkoxy)acetates

Cleavage of alkoxycarbonyl protecting groups from carbamates by t-BuNH2