Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry
Lopez Ruíz, Heraclio
2013
Heraclio López-Ruiz,* José Emilio de la Cerda-Pedro, Susana Rojas-Lima,* Imelda Pérez-Pérez, Brianda Viridiana Rodríguez-Sánchez, Rosa Santillan, and Oscar Coreño. Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry. ARKIVOC, (iii) 139-164, (2013). http://www.arkat-usa.org/get-file/47182/
Abstract
Cuprous oxide on charcoal (Cu2O/C), the preparation of which is described for the first time, catalyzes the formation of 1,4-disubstituted 1,2,3-triazoles from organic azides and terminal alkynes in good to excellent yields (69-94%). These disubstituted triazoles can be equally efficiently generated in a one-pot process from alkyl bromides, sodium azide, and terminal acetylenes in 50% aqueous isopropanol containing a suspension of the catalyst. This obviates the necessity to isolate potentially explosive organic azides.
Artículos relacionados
Study of the reactivity of squarylferrocenes. Addition of amines and aminoesters
Ylidaddukte der Penteltrichloride
Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.
Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition