Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives
Suárez Castillo, Oscar Rodolfo
2009
Suárez-Castillo Oscar R., Meléndez-Rodríguez Myriam, Castelán-Duarte Luis Enrique, Sánchez-Zavala Maricruz, Rivera-Becerril Ernesto, Morales-Ríos Martha S., Joseph-Nathan Pedro. Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives, Tetrahedron:Asymmetry 20, 23742389 (2009). ISSN 0957-4166. doi:10.1016/j.tetasy.2009.09.017
Abstract
We describe a reliable method for determining the absolute configuration of 2-(2-oxo-3-indolyl)acetamides based on analysis of the 1H NMR spectra of their phenylethylamide diastereomers. The conformational preferences for two diastereomeric amides were calculated by DFT, which matched well with the experimental results. X-ray diffraction analysis allowed us to validate the method.
Artículos relacionados
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters
Synthesis of Bromoindole Alkaloids from Laurencia brongniartii
First Total Synthesis of ()-Flustraminol B
Role of lipid peroxidation in biliary obstruction in the rat
One-potsynthesis of conformationallyrestrictedspirooxindoles
Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives