Producción Científica Profesorado

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.



Rojas Lima, Susana

2011

Rodríguez-Garnica Cristina, López-Ruiz Heraclio,* Rojas-Lima Susana, Álvarez - Hernández Alejandro, Tapia-Benavides Rafael, García-López María Concepción. Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group. Journal of the Mexican Chemical Society, 55(3), 148-153. (2011)


Abstract


Novel chiral glycinate derivatives (S)-6 and (S)-7 containing the a-phenylethyl group, were prepared and studied as potentialprecursors of enantiopure a-substituted-a-amino acids. In particular, the alkylation of enolate (S)-7-Li showed substantial (78:22 dr)stereoinduction by the N-(1-phenylethyl)benzamide chiral auxiliary.Addition of DMPU showed no appreciable effect upon the diastereoselectivity



Producto de Investigación




Artículos relacionados

Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: synthesis of...

3-Benzoyl-2-isopropyl-4-alkyloxazolidin-5-ones as Efficient and Inexpensive Sources of Enantiopure ?...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Enantioselective synthesis of ?-amino acids. Part 10: Preparation of novel ?,?- and ?,?-disubstitute...

Aroylthioureas: new organic ionophores for heavy-metal ion selective electrodes

Structural studies of spiroarsoranes derived from 2-aminophenols

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...

Synthesis and Structures of some Lithium and Sodium (Aminoalcoholato)hydrido Aluminates

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Pla...

r-Alkylation of (S)-Asparagine with Self-Regeneration of the Stereogenic Center: Enantioselective Sy...