Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reactio
Lopez Ruíz, Heraclio
2007
Susana Rojas-Lima, Lidia Santillan-Sid, Heraclio López-Ruiz, y Alejandro Alvarez-Hernandez. Diastereoselective synthesis of spiro-beta-lactams via staudinger reaction. Heterocycles 71, 531-542 (2007). DOI: 10.3987/COM-06-10942
Abstract
In this work, eleven new spiro-?-lactams have been prepared using the Staudinger reaction of isomaleimides (1a-d) and carboxylic acids (chloroacetic acid, (-)-menthoxyacetic acid (7) and an oxazolidinone derived acid (10)) in the presence of triphosgene under mild condition. All reactions have been shown to be stereoselective. The new stereogenic centers were assigned by X-ray diffraction.
Artículos relacionados
Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.
Et3B, an Efficient Mediator for Xanthate Transfer Based Radical Processes
Synthesis of new homochiral 2,3-dialkylpiperazines derived from (R)-(?)-phenylglycinol
Synthesis and Structures of some Lithium and Sodium (Aminoalcoholato)hydrido Aluminates